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Primary Antibodies
CDC42 Antibody
Background
Cell division cycle 42 isoform 1; cell division cycle 42 (GTP-binding protein, 25kD). This protein is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in at least two transcript variants.
Additional Names
CDC42,
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Description
CDC42 IgY Antibody
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Location
The gene that codes for this protein is at chromosomal location 1p36.1.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
CDC42 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
1-191
Application
CDC42 antibody can be used for the detection of CDC42 by Western blot, may also work for IHC and ICC.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
CDC42 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M, R
Protein GI Number
4757952
Protein Accession Number
NP_001782.1
Molecular Weight
6.6 kDa (calculated)
Short Description
Cell division cycle 42 isoform 1
This product belongs to the following categories:
References- Etienne-Manneville, S., Hall, A. Cdc42 regulates GSK-3-beta and adenomatous polyposis coli to control cell polarity. Nature 421: 753-756, 2003.
Datasheet 0801-W
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