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Primary Antibodies
CASP8 Antibody
Background
Caspase 8; Mch5 isoform α; FADD-homologous ICE/CED-3-like protease; MACH-α-1/2/3 protein; MACH-β-1/2/3/4 protein. This protein is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. **
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Description
Casp8 IgY Antibody
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Location
The gene that codes for this protein is at chromosomal location 2q33-q34.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
CASP8 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
266-436
Application
Casp8 antibody can be used for the detection of Casp8 by Western blot, may also work for IHC and ICC.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
CASP8 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H
Protein GI Number
15718706
Protein Accession Number
NP_203519.1
Molecular Weight
55.4 kDa (calculated)
Short Description
MACH-a-1
This product belongs to the following categories:
References- Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., Wallach, D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85: 803-815, 1996.
Datasheet 0801-W
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