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Primary Antibodies
C3 Antibody
Background
Human complement component C3. Complement C3 contains two chains linked by a disulfide bond. Its activation by a C3 convertase releases the C3a anaphylatoxin from the amino end of the α chain and generates C3b, which associates with the Bb fragment of complement factor B to form the alternative-complement-pathway C3/C5 convertase.C3a anaphylatoxin is a vasoactive peptide and a mediator of inflammation. C3b, with its highly reactive thiol group, binds to the surface of foreign particles and facilitates phagocytosis. It binds to complement C5 and renders it susceptible to proteolysis by the classical-complement-pathway C3/C5 convertase. The activity of C3b is regulated by proteolytic cleavage involving factors H and I. Its degradation products can also be biologically active.
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Description
C3 IgY Antibody
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Location
The gene that codes for this protein is at chromosomal location 19p13.3-p13.2.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
C3 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
plasma protein
Application
C3 antibody can be used for the detection of C3 by Western blot, ELISA, may also work for IHC and ICC.
Tested Application
E
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
C3 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H
Protein GI Number
4557385
Protein Accession Number
NP_000055.1
Molecular Weight
187.2 kDa (calculated)
Short Description
Complement C3
This product belongs to the following categories:
References- de Bruijn,M. H. and Fey,G. H. Human complement component C3: cDNA coding sequence and derived primary structure. Proc. Natl. Acad. Sci. U. S. A. 82 (3), 708-712 (1985).
Datasheet 0801-W
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