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Primary Antibodies
Bonzo Antibody
Background
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor. Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.
Additional Names
Bonzo (CT), STRL33
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Description
Left: Western blot analysis of Bonzo in SW1353 total cells lysate with Bonzo antibody at 1:1000 dilution.
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Source
Bonzo antibody was raised against a peptide corresponding to amino acids 319 to 338 of human origin. The sequence of this peptide is identical to those of macaque and African green monkey.
Purification
Antibody is DEAE purified
Clonality / Clone
This is a polyclonal antibody.
Host
Bonzo antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Human Bonzo (C-Terminus) Peptide (Cat. No. 1170P)
Application
Bonzo antibody can be used for detection of Bonzo by Western blot at 1:1000 dilution.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat. No. 1170P - Bonzo Peptide
Storage
Bonzo antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1214 - SW1353 Cell Lysate
Species Reactivity
H
Protein GI Number
2253422
Protein Accession Number
AAB64221
Short Description
(CT) HIV coreceptor
This product belongs to the following categories:
Related Products
References- Deng HK, Unutmaz D, KewalRamani VN, Littman DR. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 1997;388:296-300
- Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med 1997;185:2015-23
- Alkhatib G, Liao F, Berger EA, Farber JM, Peden KW. A new SIV co-receptor, STRL33. Nature 1997;388:238
- Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL, Baggiolini M, Arenzana-Seisdedos F, Moser B. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. Curr Biol 1997;7:652-60 (RD1299)
Datasheet 08-02W
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