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Primary Antibodies
BNP2 Monoclonal Antibody
Background
BNP (brain natriuretic peptide) belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. ANP and BNP act mainly as cardiac hormones, produced primarily by the atrium and ventricle, respectively, while the gene encoding C-type natriuretic peptide is expressed mainly in the brain. BNP circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. It is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic.
Additional Names
BNP, NPPB
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Description
Immunohistochemical analysis of paraffin - embedded human normal myocardium showing cytoplasma localization using BNP2 antibody with DAB staining.Immunohistochemical analysis of paraffin - embedded human brain tissue(A) and human thymus tissue(B), showing cytoplasmic localization using anti - S100B antibody with DAB staining.
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Clonality / Clone
This is a monoclonal antibody. Clone 9H6B4.
Isotype
IgG1
Host
BNP2 monoclonal antibody was raised in mouse.
Please use anti-mouse secondary antibodies.
Immunogen
Synthetic peptide corresponding to aa (Gly-Leu-Gln-Glu-Gln-Arg-Asn-His-Leu-Gln-Gly-Lys-Leu-Cys) of human BNP2.
Application
IHC(P):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Tested Application
IHC
Storage
BNP2 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1301 - Human Heart Tissue Lysate
Species Reactivity
H
Protein GI Number
4879
Short Description
Belongs to a family of structurally similar peptide hormones
This product belongs to the following categories:
Related Products
References- Dawson A. Struthers AD. Expert Opin Biol Ther. 2003, Feb, 3(1):107-12. Review.
- Pfister R. Erdmann E. Schneider CA. Dtsch Med Wochenschr. 2003,May 2, 128(18):1007-12.
Datasheet 0903-W
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