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Primary Antibodies
Aurora-Related Kinase 1 Antibody
Background
ARK1, an Aurora/IPL1-like protein kinase, functions in centrosome separation, duplication, and maturation and in bipolar spindle assembly and stability. The protein has been shown to localize to centrosomes in S phase as soon as centrioles have been duplicated, and to be degraded in early G1. ARK1 phosphorylation is induced by okadaic acid treatment in vivo. Activated ARK1 has been shown to phosphorylate the spindle apparatus-associated protein, TPX2, and it is believed to be targeted to the spindle apparatus by this protein. At least three alternative splice forms have been reported; however, the alternative splice sites are located in the 5’-untranslated region and appear to have no effect on protein translation. ARK1 has been identified as an oncogene that is overexpressed in several types of solid tumors and tumor cell lines, including those from breast and colon. Additionally, overexpression of ARK1 has been implicated in mechanisms leading to mitotic spindle aberrations, aneuploidy, and genomic instability.
Additional Names
AURKA, AIK, ARK1, AURA, AURORA-A, AURORA2, BTAK, EC 2.7.11.1, HARK1, MGC34538, STK15, STK6, STK7, Aurora-A, Aurora-related kinase 1, Ayk1, btak, HsAIRK1, IAK1, Serine/theonine kinase 15, serine/threonine kinase 6 , stk15, stk6
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Description
Left: Immunohistochemistry staining of Aurora-Related Kinase 1 in testis (formalin-fixed paraffin-embedded) using Aurora-Related Kinase 1 antibody.
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Purification
Immunoaffinity Chromatography
Clonality / Clone
This is a polyclonal antibody.
Isotype
IgG
Host
Aurora-Related Kinase 1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Aurora-Related Kinase 1 antibody was raised against a modified peptide of Aurora-Related Kinase 1. (Human)
Application
Aurora-Related Kinase 1 antibody can be used for detection of Aurora-Related Kinase 1 by WB, IHC-parafin (1:50).
Tested Application
WB, IHC
Buffer
Aurora-Related Kinase 1 antibody is supplied in phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.
Storage
Aurora-Related Kinase 1 antibody can be stored at 4˚C or -20˚C, Avoid repeated freezing and thawing.
Species Reactivity
H
Formulation
Volume: 50 μl
Short Description
Aurora-Related Kinase 1
This product belongs to the following categories:
Datasheet 09-01W
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