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Primary Antibodies
Amphetamine Monoclonal Antibody (Clone 6F2)
Background
Amphetamine (AMPH) is a potent central nervous system (CNS) stimulant with additional peripheral sympathomimetic effects. AMPH has been used clinically in the treatment of obesity, minimal brain dysfunction, narcolepsy, depression and to counter fatigue and are also subjected to widespread abuse. Following the acute administration of the AMPHs there is an increase in blood pressure, heart rate, respiration, sweating and tremor. The behavioral manifestations include species specific stereotypic behavior, anorexia, sleeplessness, hyperexcitability, and hyperactivity. AMPH is a indirect agonists, causing the release of newly synthesized norepinephrine and dopamine and blocking the reuptake of these transmitters from the synapse, resulting to an increase in the concentration of catecholamines in the synapse as well as an overall increase in catecholaminergic activity in the brain
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Description
Left: A competitive ELISA was performed using various drugs at a concentration of 10 ng/ml. Only amphetamine was able to block the binding of the antibody to the antigen.
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Purification
Mouse IgG1 is purified by ammonium sulfate precipitation.
Clonality / Clone
This is a monoclonal antibody. Clone 6F2
Host
Amphetamine Monoclonal antibody (Clone 6F2) was raised in mouse.
Please use anti-mouse IgG secondary antibodies.
Immunogen
Amphetamine (Clone 6F2) monoclonal antibody was (6F2) was made against a BSA-amphetamine conjugate.
Application
Tested Application
E
Storage
Amphetamine Monoclonal antibody (Clone 6F2) is supplied in PBS buffer containing 0.02% sodium azide. For longer periods of storage, store at -20ºC. Avoid repeat freeze-thaw cycle.
Species Reactivity
n/a
Molecular Weight
44kDa
Short Description
Anti-Amphetamine
This product belongs to the following categories:
References- Bowyer, J. F., et al., (2004) Neurotoxicology 25(4), 555-72
Datasheet 0802-W
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