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Primary Antibodies
Aldh3A2 Antibody
Background
Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder. Patients with this disorder display ichthyosis, mental retardation and spastic diplegia. The pathogenesis of the cutaneous and neurological symptoms is thought to result from abnormal lipid accumulation in the membranes of skin and brain, the formation of aldehyde Schiff base adducts with amine-containing lipids or proteins, or defective eicosanoid metabolism. At least four isoforms of Aldh3A2 are known to exist. This antibody is predicted to have no cross-reactivity to Aldh3A1.
Additional Names
Aldh3A2,Aldehyde dehydrogenase family3 member A2, fatty aldehyde dehydrogenase, FALDH, ALDH10
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Description
Left: Western blot analysis of Aldh3A2 in mouse liver lysate with Aldh3A2 antibody at (A) 1 and (B) 2 μg/ml.
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Source
Aldh3A2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human Aldh3A2.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
Aldh3A2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
Aldh3A2 antibody can be used for detection of Aldh3A2 by Western blot at 1 – 2 μg/ml.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 4789P - Aldh3A2 Peptide
Storage
Aldh3A2 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1404 - Mouse Liver Tissue Lysate
Species Reactivity
H, M
Protein GI Number
73466520
Protein Accession Number
NP_001026976
Short Description
Fatty acid dehydrogenase
This product belongs to the following categories:
Related Products
References- Vasiliou V and Pappa A. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. Pharmacology 2000; 61:192-8.
- Rizzo WB. Sjogren-Larsson syndrome: molecular genetics and biochemical pathogenesis of fatty aldehyde dehydrogenase deficiency. Mol. Genet. Metab. 2007; 90:1-9.
Datasheet 08-01W
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