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Recombinant Proteins
Activin B Recombinant Protein
Background
Activin B is a TGF-β family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.
Additional Names
Activin beta-B, Inhibin beta-2
Location
GLECDGRTNL CCRQQFFIDF RLIGWNDWII APTGYYGNYC EGSCPAYLAG VPGSASSFHT AVVNQYRMRG LNPGTVNSCC IPTKLSTMSM LYFDDEYNIV KRDVPNMIVE ECGCA
Source
(BTI-Tn-5B1-4) High-5 Insect cells*
Reactivity
n/a
Preparation
The ED50 was determined by its ability to inhibit the proliferation of murine MPC - 11 cells is ? 2ng/ml, corresponding to a specific activity of ? 5 x 105 units/mg.
Tested Application
n/a
Storage
The lyophilized Activin B recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Activin B is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Activin B recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Species Reactivity
n/a
Purity
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Short Description
Recombinant Human Activin-B
This product belongs to the following categories:
Datasheet 0904-W
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