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Recombinant Proteins
Activin A Recombinant Protein
Background
Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
Additional Names
Location
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Source
E.coli
Reactivity
n/a
Preparation
The ED50 was determined by its ability to inhibit the proliferation of murine MPC - 11 cells is ? 2.0 ng/ml, corresponding to a specific activity of ? 5 x 105 units/mg.
Tested Application
n/a
Storage
The lyophilized Activin A recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Activin A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Activin A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Species Reactivity
n/a
Purity
Greater than 97% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Short Description
Recombinant Human Activin A
This product belongs to the following categories:
Datasheet 0904-W
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