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Primary Antibodies
ATR Antibody
Background
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
Additional Names
ATR, EC 2.7.11.1, FRP1, MEC1, SCKL, SCKL1, ataxia telangiectasia and Rad3 related, FRAP-RELATED PROTEIN 1, protein kinase atr
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Description
Left: Immunohistochemistry staining of ATR in brain, cerebellum (formalin-fixed paraffin-embedded) using ATR antibody.
Below: Immunohistochemistry staining of ATR in skin (formalin-fixed paraffin-embedded) using ATR antibody.
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Other Product Images
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Purification
Ion Exchange Chromatography
Clonality / Clone
This is a polyclonal antibody.
Host
ATR antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
ATR antibody was raised against the Internal domain of ATR. (Human)
Application
ATR antibody can be used for detection of ATR by WB, IHC-parafin (0.5 - 1 μg/ml).
Tested Application
WB, IHC
Buffer
ATR antibody is supplied in PBS, 0.02% sodium azide.
Storage
ATR antibody can be stored at 2-8˚C for up to 1 year. Avoid repeated freeze-thaw cycles.
Species Reactivity
M, R
Formulation
Weight: 50 μg
Volume: 250 μl
Concentration: 0.2 mg/ml
Short Description
Ataxia Telangiectasia and Rad3 Related
This product belongs to the following categories:
Datasheet 09-01W
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