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Primary Antibodies
ATM Monoclonal Antibody
Background
ATM-2C1 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation. The ATM gene product is a 370 kD nuclear phosphoprotein with C-terminal homology to phosphatidylinositol 3-kinase. ATM is involved in the induction of a DNA damage control pathway. Mutations in the ATM gene cause neuronal degeneration, gonadal abnormalities, and immune deficiencies as part of the hereditary disease ataxia telangiectasia.
Additional Names
ATM, AT, AT1, ATA, ATC, ATD, ATDC, ATE, DKFZP781A0353, EC 2.7.11.1, MGC74674, T-PLL, TEL1, TPLL, ataxia telangiectasia, ataxia telangiectasia mutated
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Description
Left: Immunohistochemistry staining of ATM in kidney (formalin-fixed paraffin embedded) using ATM monoclonal antibody.
Below: Immunohistochemistry staining of ATM in testis (formalin-fixed paraffin embedded) using ATM monoclonal antibody.
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Other Product Images
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Purification
Protein G Column
Clonality / Clone
This is a monoclonal antibody. Clone 2C1.
Isotype
IgG1
Host
ATM monoclonal antibody was raised in mouse.
Please use anti-mouse secondary antibodies.
Immunogen
ATM monoclonal antibody was raised against recombinant protein expressed in E. coli corresponding to amino acids 2577-3056 of ATM. (Human)
Application
ATM antibody can be used for detection of ATM by WB, IP, IF, IHC-parafin (5 μg/ml).
Tested Application
WB, IHC, IF, IP
Buffer
ATM monoclonal antibody is supplied in PBS, pH 7.4. Preservative free.
Storage
ATM monoclonal antibody can be stored at 4˚C or -20˚C, Avoid repeated freezing and thawing.
Species Reactivity
M, R, Mk
Formulation
Weight: 50 μg
Concentration: 1 mg/ml
Short Description
Ataxia Telangiectasia Mutated
This product belongs to the following categories:
Datasheet 09-01W
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