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Primary Antibodies
APC2 Antibody
Background
APC2, also known as Anaphase promoting complex subunit 2, APC2, Cyclosome subunit 2, and ANAPC2, is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/cyclosome protein complex promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitors, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains at least eleven subunits. The composition of APC is highly conserved in organisms from yeast to humans. APC2 is a cullin family member that interacts through the cullin domain with ANAPC11 and UBCH10.
Additional Names
APC2, ANAPC2, APCL, KIAA1406, apcl protein
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Description
Left: Immunohistochemistry staining of APC2 in skin (formalin-fixed paraffin-embedded) using APC2 antibody.
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Purification
Sterile Filtration
Clonality / Clone
This is a polyclonal antibody.
Host
APC2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
APC2 antibody was raised against amino acids 810-822 of APC2. (Human)
Application
APC2 antibody can be used for detection of APC2 by WB (1:500 - 1:1000), IP, ELISA (1:2000 - 1:10000), IHC-parafin (1:500).
Tested Application
E, WB, IHC, IP
Buffer
APC2 antibody is supplied in 0.01% sodium azide.
Storage
APC2 antibody can be stored at 4˚C or -20˚C. Avoid repeated freezing and thawing.
Species Reactivity
H
Formulation
Volume: 50 μl
Concentration: 85 mg/ml
Short Description
APCL Protein
This product belongs to the following categories:
Datasheet 09-01W
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