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Primary Antibodies
APC Antibody
Background
Although the metabolic function of the tumor suppressor APC gene is not known, it is involved in maintaining cytoplasmic levels of the Wingless (Wg)/Wnt effector (Armadillo)/beta-catenin at a steady state. During development, beta-catenin is involved in cell growth and axis patterning. APC binds beta-catenin preventing it to act as a transcription factor and targets it for destruction. Mutations in the APC gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy such as Gardner syndrome and colorectal cancer.
Additional Names
APC, DP2, DP2.5, DP3, FAP, FPC, GS, adenomatous polyposis coli protein, apc, apc tumor suppressor gene, dp2, dp2.5, fpc, gs
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Description
Left: Immunohistochemistry staining of APC in colon (formalin-fixed paraffin-embedded) using APC antibody.
Below: Immunohistochemistry staining of APC in thyroid (formalin-fixed paraffin-embedded) using APC antibody.
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Other Product Images
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Purification
Immunoaffinity Chromatography
Clonality / Clone
This is a polyclonal antibody.
Host
APC antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
APC antibody was raised against a peptide from the C-terminus of APC. (Human)
Application
APC antibody can be used for detection of APC by IHC-parafin (10 μg/ml).
Tested Application
IHC
Buffer
APC antibody is supplied in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
Storage
APC antibody can be stored at 4˚C, avoid freezing.
Species Reactivity
M, R, C, S
Formulation
Weight: 50 μg
Volume: 250 μl
Concentration: 0.2 mg/ml
Short Description
Adenomatous Polyposis Coli Protein
This product belongs to the following categories:
Datasheet 09-01W
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