|
Primary Antibodies
AKT2 Monoclonal Antibody
Background
Akt, protein kinase B (PKB), is a serine/threonine kinase, which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers. AKT2 encodes a RAC/AKT-type protein kinase that contains a N-terminal pleckstrin-homology (PH) domain and a central catalytic domain closely related to both cAMP-dependent protein kinase and protein kinase C. The protein is a member of PI3K-mediated signalling pathways associated with the regulation of proliferation, survival, protein synthesis, and metabolism. It is activated by a variety of growth factors. AKT2 has been shown to be transcriptionally regulated by MyoD and to activate MyoD-myocyte enhancer binding factor-2 (MEF2) transactivation activity during muscle differentiation. Glycogen synthase kinase 3 (GSK-3) also has been shown to be a downstream target of AKT2. The AKT2 gene is one of the human homologues of v-akt, the transduced oncogene of the AKT8 virus, which induces lymphomas in mice. It has been implicated in breast, ovarian, and pancreatic cancers.
Additional Names
AKT2, EC 2.7.11.1, PKBBETA, PRKBB, RAC-BETA, RAC-PK-BETA, akt2/pkbbeta, protein kinase b beta, RAC-PK-beta, v-akt murine thymoma viral oncogene homolog 2
Purification
Ascites
Clonality / Clone
This is a monoclonal antibody. Clone 95C657.1.2.
Isotype
IgM
Host
AKT2 monoclonal antibody was raised in mouse.
Please use anti-mouse secondary antibodies.
Immunogen
AKT2 monoclonal antibody was raised against amino acids 106-123 of AKT2. (Human)
Application
AKT2 antibody can be used for detection of AKT2 by WB (1:500 - 1:1000), IHC-parafin (1:50).
Tested Application
WB, IHC
Buffer
AKT2 monoclonal antibody is supplied as Ascites fluid in PBS, 0.05% BSA, 0.05% sodium azide.
Storage
AKT2 monoclonal antibody can be stored at -70˚C for long term storage, and 4˚C for short term storage.
Species Reactivity
H
Formulation
Volume: 50 μl
Short Description
V-Akt Murine Thymoma Viral Oncogene Homolog 2
This product belongs to the following categories:
Datasheet 09-01W
|
|
