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Primary Antibodies
AKT1 Antibody
Background
Serine/threonine protein kinase; Murine thymoma viral (v-akt) oncogene homolog-1. AKT1 is a serine-threonine protein kinase. It is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
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Description
AKT IgY Antibody
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Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
AKT1 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
2-200
Application
AKT antibody can be used for the detection of AKT by Western blot, may also work for IHC and ICC.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
AKT1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M, R, B, X
Protein GI Number
4885061
Protein Accession Number
NP_005154.1
Molecular Weight
55.7 kDa (calculated)
Short Description
Serine/threonine protein kinase
This product belongs to the following categories:
Related Products
References- Brunet,A., Bonni,A., Zigmond,M. J., Lin,M. Z., Juo,P., Hu,L. S., Anderson,M. J., Arden,K. C., Blenis,J. and Greenberg,M. E. TITLE Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor JOURNAL Cell 96 (6), 857-868 (1999).
Datasheet 0801-W
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