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Primary Antibodies
AIFM1 Antibody
Background
Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed.
Additional Names
AIFM1, aif, APOPTOSIS-INDUCING FACTOR, pdcd8, Programmed Cell Death 8
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Description
Left: Immunohistochemistry staining of AIFM1 in kidney (formalin-fixed paraffin-embedded) using AIFM1 antibody.
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Purification
Purified
Clonality / Clone
This is a polyclonal antibody.
Host
AIFM1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
AIFM1 antibody was raised against amino acids 593 to 606 of AIFM1. (Human)
Application
AIFM1 antibody can be used for detection of AIFM1 by WB, IHC-parafin (20 μg/ml).
Tested Application
WB, IHC
Buffer
AIFM1 antibody is supplied in PBS, 0.02% sodium azide.
Storage
AIFM1 antibody can be stored at 4˚C or -20˚C, Avoid repeated freezing and thawing.
Species Reactivity
H
Formulation
Weight: 50 μg
Short Description
Apoptosis-inducing Factor
This product belongs to the following categories:
Datasheet 09-01W
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