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Primary Antibodies
AFP Antibody
Background
α-1-fetoprotein. α-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. α-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of α-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the α-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. α-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of α-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
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Description
AFP IgY Antibody
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Location
The gene that codes for this protein is at chromosomal location 4q11-q13.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
AFP antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
180-420
Application
AFP antibody can be used for the detection of AFP by Western blot, may also work for IHC and ICC.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
AFP antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H
Protein GI Number
4501989
Protein Accession Number
NP_001125.1
Molecular Weight
68.7 kDa (calculated)
Short Description
a-1-fetoprotein
This product belongs to the following categories:
References- Gabant, P., Forrester, L., Nichols, J., Van Reeth, T., De Mees, C., Pajack, B., Watt, A., Smitz, J., Alexandre, H., Szpirer, C., Szpirer, J. Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Proc. Nat. Acad. Sci. 99: 12865-12870, 2002.
Datasheet 0801-W
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