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Primary Antibodies
ADAM23 Antibody
Background
FUNCTION: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
SUBUNIT: Ligand for integrin α-V/γ-3.
SIMILARITY: Contains 1 peptidase M12B domain.
SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein (Potential). Secreted protein. Isoform Gamma.
TISSUE SPECIFICITY: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
DEVELOPMENTAL STAGE: Highly expressed in the fetal brain.
DOMAIN:A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
SUMMARY: This protein is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is highly expressed in the brain and may function as an integrin ligand in the brain.
Additional Names
ADAM 23, A disintegrin and metalloproteinase domain 23, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3, MDC-3
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Description
Left: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
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Location
The gene that codes for this protein is at chromosomal location 2q33.
Purification
Immunoaffinity Purified
Clonality / Clone
This is a polyclonal antibody.
Host
ADAM23 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
72-144
Application
ADAM 23 antibody can be used for the detection of ADAM 23 by Western Blot.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
ADAM23 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H
Protein GI Number
4501913
Protein Accession Number
NP_003803.1
Molecular Weight
91.9 kDa (calculated)
Short Description
A disintegrin and metalloproteinase domain 23
This product belongs to the following categories:
Datasheet 0801-W
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