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Primary Antibodies
ADAM17 Antibody
Background
Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. ADAM17 is a Metallopeptidase M12B type protease.
Additional Names
ADAM17, CD156B, CSVP, EC 3.4.24.86, MGC71942, TACE, adam17, CD156b antigen, cSVP, Snake venom-like protease, TNF alpha convertase, tnf-alpha converting enzyme, tumor necrosis factor alpha converting enzyme
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Description
Left: Immunohistochemistry staining of ADAM17 in skeletal muscle (formalin-fixed paraffin-embedded) using ADAM17 antibody.
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Purification
Immunoaffinity Chromatography
Clonality / Clone
This is a polyclonal antibody.
Host
ADAM17 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
ADAM17 antibody was raised against amino acids 807 to 823 of ADAM17. (Human)
Application
ADAM17 antibody can be used for detection of ADAM17 by WB, IHC-parafin (20 μg/ml).
Tested Application
WB, IHC
Buffer
ADAM17 antibody is supplied in PBS, 0.02% sodium azide.
Storage
ADAM17 antibody can be stored at 4˚C or -20˚C. Avoid repeated freezing and thawing.
Species Reactivity
H, M, R
Formulation
Weight: 50 μg
Concentration: 0.5 mg/ml
Short Description
A Disintegrin And Metalloproteinase Domain 17
This product belongs to the following categories:
Datasheet 09-01W
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