|
Primary Antibodies
ADAM10 Antibody
Background
Proinflammatory cytokine tumor necrosis factor-a? (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4).
Additional Names
ADAM10, CD156C, EC 3.4.24.81, HST18717, KUZ, MADM, 1700031C13Rik, a disintegrin and metalloproteinase 10, adam 10, adam10, kuz, kuzbanian
|
Description
Left: Immunohistochemistry staining of ADAM10 in skeletal muscle (formalin-fixed paraffin-embedded) using ADAM10 antibody.
|
Purification
DEAE-column Chromatography
Clonality / Clone
This is a polyclonal antibody.
Host
ADAM10 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
ADAM10 antibody was raised against a region near the carboxy terminus of ADAM10. (Human)
Application
ADAM10 antibody can be used for detection of ADAM10 by WB (1:500 - 1:2000), ELISA (1:5000 - 1:20000), IF (1:250 - 1:1000), IHC-parafin (2.5 μg/ml).
Tested Application
E, WB, IHC, IF
Buffer
ADAM10 antibody is supplied in 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.02% sodium azide.
Storage
ADAM10 antibody can be stored at 4˚C or -20˚C, Avoid repeated freezing and thawing.
Species Reactivity
M, R, C
Formulation
Weight: 50 μg
Concentration: 1 mg/ml
Short Description
A Disintegrin And Metalloproteinase Domain 10
This product belongs to the following categories:
Datasheet 09-01W
|
|
