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Primary Antibodies
ACTL6A Antibody
Background
BAF53α isoform 1. This protein is a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This protein is a 53 kDa subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with β-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix.
Additional Names
BAF53A
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Description
BAF53A IgY Antibody
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Location
The gene that codes for this protein is at chromosomal location 3q26.33.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
ACTL6A antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
1-429
Application
BAF53A antibody can be used for the detection of BAF53A by Western blot, may also work for IHC and ICC.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
ACTL6A antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M
Protein GI Number
4757718
Protein Accession Number
NP_004292.1
Molecular Weight
47.5 kDa (calculated)
This product belongs to the following categories:
References- Zhao, K., Wang, W., Rando, O. J., Xue, Y., Swiderek, K., Kuo, A., Crabtree, G. R. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell 95: 625-636, 1998.
Datasheet 0801-W
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