|
Primary Antibodies
ABL1 Antibody
Background
ABL1, an Abl type protein kinase, is associated with cell differentiation, cell division, cell adhesion and stress response. Kinase activity of nuclear ABL1 is mediated by retinoblastoma protein. Additionally, ABL1 has been shown to bind nuclear DNA, and this binding activity is regulated by CDC2-mediated phosphorylation. ABL1 (-/-) mice are osteoporotic and display increased perinatal mortality, reduced fertility, foreshortened crania and defects in the maturation of B cells in bone marrow. At least two mRNA isoforms have been reported, 6- or 7-kb, with alternatively spliced first exons joined to the common exons 2-11. Alterations of ABL1 by chromosomal rearrangement or viral transduction lead to malignant transformation. Further, a very long intron in the ABL1 gene is a target for translocations. Translocations of ABL1 to the breakpoint cluster region (BCR) on chromosome 22 lead to chronic myeloid leukemia and acute lymphocytic leukemia.
Additional Names
ABL1, ABL, C-ABL, EC 2.7.10.2, JTK7, P150, V-ABL, Abl, Bcr-Abl, c-abl, jtk7, p150, proto-oncogene tyrosine-protein kinase abl, v-abl, v-abl abelson murine leukemia viral oncogene homolog 1
|
Description
Left: Immunohistochemistry staining of ABL1 in spleen using ABL1 antibody.
|
Purification
Immunoaffinity Chromatography
Clonality / Clone
This is a polyclonal antibody.
Isotype
IgG
Host
ABL1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Specificity
pTyr412
Immunogen
ABL1 antibody was raised against amino acids surrounding Tyrosine 412 of ABL1. (Human)
Application
ABL1 antibody can be used for detection of ABL1 by IHC-parafin (20 μg/ml).
Tested Application
IHC
Buffer
ABL1 antibody is supplied in PBS, 0.02% sodium azide, 50% glycerol.
Storage
ABL1 antibody can be stored at -70˚C for long term storage, and -20˚C for short term storage.
Species Reactivity
M
Formulation
Weight: 50 μg
Short Description
Abelson Murine Leukemia Viral Oncogene Homolog 1
This product belongs to the following categories:
Datasheet 09-01W
|
|
