|
Primary Antibodies
ABCB1 Antibody
Background
ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.
Additional Names
ABCB1, ABC20, CD243, CLCS, EC 3.6.3.44, GP170, MDR1, P-GP, PGY1, Abcb1, Abcb1b, ATP-binding cassette sub-family B (MDR/TAP) member 1, CD243 antigen, DOXORUBICIN RESISTANCE, Multidrug Resistance 1, multidrug resistance gene 1, P-Glycoprotein 1, P-gp
|
Description
Left: Immunohistochemistry staining of ABCB1 in kidney (formalin-fixed paraffin-embedded) using ABCB1 antibody.
|
Purification
Immunoaffinity Chromatography
Clonality / Clone
This is a polyclonal antibody.
Host
ABCB1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
ABCB1 antibody was raised against amino acids 262-277 of ABCB1. (Human)
Application
ABCB1 antibody can be used for detection of ABCB1 by WB (1:200 - 1:2000), ELISA (1:10000 - 1:50000), IHC-parafin (5 μg/ml).
Tested Application
E, WB, IHC
Buffer
ABCB1 antibody is supplied in 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Storage
ABCB1 antibody can be stored at 4˚C or -20˚C, Avoid repeated freezing and thawing. Store undiluted.
Species Reactivity
M, R, D, Mk
Formulation
Weight: 50 μg
Concentration: 1 mg/ml
Short Description
ATP-Binding Cassette
This product belongs to the following categories:
Datasheet 09-01W
|
|
