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Primary Antibodies
ABCA1 Monoclonal Antibody
Background
This membrane-associated protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extracellular and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangiers disease and familial high-density lipoprotein deficiency. ABCA1 (ATP-binding Cassette, Sub-family A, Member 1), also known as ABC1 (ABC Transporter 1) or CERP (Cholesterol efflux regulatory protein), is a member of the family of ATP-binding cassette (ABC) transporters. It is a cAMP-dependent, sulfonylurea-sensitive traffic ATPase, which is located at the plasma membrane and plays a key role in the cellular lipid removal pathway. ABCA1 supports apolipoprotein A-I (APOA1)-mediated cellular efflux of cholesterol and choline-phospholipids into the blood circulation; therefore, ABCA1 defects result in reduced plasma level of high density lipoproteins (HDL) combined with the tissue deposition of cholesteryl esters. More commonly, ABCA1 inherited defects are associated with a milder condition, so-called familial hypoalphalipoproteinemia (FHA). FHA patients, similar to Tangier disease patients, demonstrate a very evident decrease of HDL level; however, they lack clinical manifestations.
Additional Names
ABCA1, ABC-1, ABC1, CERP, FLJ14958, HDLDT1, TD, TGD, abca1, ATP-binding cassette 1, ATP-binding cassette transporter 1, ATP-binding cassette transporter A1, cholesterol efflux regulatory protein (cerp), high density lipoprotein deficiency Tangier type 1, Tangier disease, td
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Description
Left: Immunohistochemistry staining of ABCA1 in skeletal muscle (formalin-fixed paraffin-embedded) using ABCA1 Monoclonal antibody.
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Purification
Immunoaffinity Chromatography
Clonality / Clone
This is a monoclonal antibody.
Isotype
IgG1
Host
ABCA1 monoclonal antibody was raised in mouse.
Please use anti-mouse secondary antibodies.
Immunogen
ABCA1 monoclonal antibody was raised against amino acids 1800-2260 of ABCA1. (Human)
Application
ABCA1 monoclonal antibody can be used for detection of ABCA1 by WB, ELISA, IHC-parafin (minimum working concentration: 10 μg/ml maximum working concentration: 10 μg/ml).
Tested Application
E, WB, IHC
Buffer
ABCA1 monoclonal antibody is supplied in PBS, pH 7.4, 0.05% sodium azide.
Storage
ABCA1 monoclonal antibody can be stored at 4˚C or -20˚C. Avoid repeated freezing and thawing.
Species Reactivity
M, C
Formulation
Weight: 50 μg
Concentration: 1 mg/ml
Short Description
ATP-Binding Cassette, Sub-Family A
This product belongs to the following categories:
Datasheet 09-01W
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