Datasheet

GPR15 Antibody
CATALOG NUMBER: 2101

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, ICC, WB
APPLICATIONS:GPR15 antibody can be used for detection of GPR15 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1205 - Jurkat Cell Lysate
 2) Cat. No. 1203 - A549 Cell Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 40 kDa

Observed: 49 kDa
IMMUNOGEN:GPR15 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human GPR15.

The immunogen is located within the first 50 amino acids of GPR15.
HOST SPECIES:Rabbit

Properties

PURIFICATION:GPR15 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:GPR15 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:GPR15 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:GPR15 Antibody: BOB
ACCESSION NO.:U34806
PROTEIN GI NO.:1171145
OFFICIAL SYMBOL:GPR15
GENE ID:2838

Background

BACKGROUND:GPR15 Antibody: Human immunodeficiency virus (HIV) and related viruses require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four other molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. GPR15, also known as BOB, is a G protein-coupled receptor that serves as coreceptor for the simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1.
REFERENCES: 1) Heiber M, Marchese A, Nguyen T, et al. A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3. Genomics 1996; 32:462-5
2) Deng HK, Unutmaz D, KewalRamani VN, et al. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 1997; 388:296-300
3) Farzan M, Choe H, Martin K, et al. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J. Exp. Med. 1997;186:405-11.

For Research Use Only