Datasheet

GLUL Monoclonal Antibody
CATALOG NUMBER: PM-7209

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:GLUL antibody can be used for detection of GLUL by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1303 - Human Brain Tissue Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 41 kDa
IMMUNOGEN:Mouse monoclonal GLUL antibody was raised against a 15 amino acid peptide near the amino terminus of human GLUL.
HOST SPECIES:Mouse

Properties

PURIFICATION:GLUL Monoclonal Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:GLUL Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:GLUL Monoclonal antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Monoclonal
ISOTYPE:IgG1
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:GLUL Monoclonal Antibody: Glutamate ammonia ligase, glutamine synthase, glutamate decarboxylase, GLNS, GS, PIG43, PIG59, cell proliferation-inducing protein 59
ACCESSION NO.:NP_002056
PROTEIN GI NO.:19923206
OFFICIAL SYMBOL:GLUL
GENE ID:2752

Background

BACKGROUND:GLUL Monoclonal Antibody: Glutamate ammonia ligase (GLUL) belongs to the glutamine synthetase family and catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. GLUL is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Recent studies have suggested that elevated levels of GLUL may be an early marker for hepatocellular carcinoma.
REFERENCES: 1) Wang Y, Kudoh J, Kubota R, et al. Chromosomal mapping of a family of human glutamine synthetase genes: functional gene (GLUL) on 1q25, pseudogene (GLULP) on 9p13, and three related genes (GLULL1, GLULL2, GLULL3) on 5q33, 11p15, and 11q24.
2) Long J, Lang ZW, Wang HG, et al. Glutamine synthetase as an early marker for hepatocellular carcinoma based on proteomic analysis of resected small hepatocellular carcinomas. Hepatobiliary Pancreat. Dis. Int. 2010; 9:296-305.

For Research Use Only