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Avian Influenza Nonstructural Protein 2 Antibody
CATALOG NUMBER: 3917

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Virus
TESTED APPLICATIONS:ELISA
APPLICATIONS:Avian Influenza Nonstructural Protein 2 antibody can be used for the detection of the Avian Influenza Nonstructural Protein 2 protein from influenza A in ELISA.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
IMMUNOGEN:Avian Influenza Nonstructural Protein 2 antibody was raised against a synthetic peptide corresponding to 14 amino acids near the middle of the Avian Influenza Nonstructural Protein 2 protein.

Efforts were made to use relatively conserved regions of the viral sequence as the antigen.

The immunogen is located within amino acids 40 - 90 of Avian Influenza Nonstructural Protein 2.
HOST SPECIES:Rabbit

Properties

PURIFICATION:Avian Influenza Nonstructural Protein 2 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:Avian Influenza Nonstructural Protein 2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Avian Influenza Nonstructural Protein 2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Avian Influenza Nonstructural Protein 2 Antibody:
ACCESSION NO.:ABC72654
PROTEIN GI NO.:85680916

Background

BACKGROUND:Avian Influenza Nonstructural Protein 2 Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes, including the so-called "avian flu" or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by the influenza virus is the nonstructural protein (NS) 2. NS2 binds to the influenza matrix protein M1 that is bound to the ribonucleoprotein (RNP) complex and mediates the contact between the M1/RNP complex and the cellular exportin CRM, but does not interact with nucleosomes.
REFERENCES: 1) Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289:179-186.
2) Alexander DJ. A review of avian influenza. Proceedings of the European Society for Veterinary Virology (ESVV) Symposium on Influenza Viruses of Wild and Domestic Animals. Vet. Microbiol. 2000; 74:3-13.
3) Neumann G, Hughes MT and Kawaoka Y. Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1. EMBO J. 2000; 19:6751-8.
4) Garcia-Robles I, Akarsu H, Muller CW, et al. Interaction of influenza virus proteins with nucleosomes. Virology 2005; 332:329-36.

For Research Use Only