Datasheet

APRIL Antibody
CATALOG NUMBER: 2415

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:H, M
TESTED APPLICATIONS:E, WB, IHC
APPLICATIONS:APRIL antibody can be used for detection of APRIL by Western blot at 1 - 4 μg/mL. A 27 kDa band was detected. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1205 - Jurkat Cell Lysate
 2) Cat. No. 1312 - Human Prostate Tissue Lysate
PREDICTED MOLECULAR WEIGHT:27 kDa
IMMUNOGEN:APRIL antibody was raised against a synthetic peptide corresponding to amino acids within a extracellular domain of human APRIL.
HOST SPECIES:Rabbit

Properties

PURIFICATION:APRIL Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:APRIL Antibody is supplied in PBS containing 0.02% sodium azide.
STORAGE CONDITIONS:APRIL antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:APRIL Antibody: APRIL, CD256, TALL2, ZTNF2, TALL-2, TRDL-1, UNQ383/PRO715, APRIL, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand
ACCESSION NO.:NP_003799
PROTEIN GI NO.:4507599

Background

BACKGROUND
APRIL Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1α (for TNF related death ligand 1α) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
REFERENCES
1) Hahne M, Kataoka T, Schroter M, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J Exp Med. 1998;188(6):1185-90.
2) Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol. 1999;65(5):680-3.
3) Kelly K, Manos E, Jensen G, et al. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. 2000;60(4):1021-7.
4) Yu G, Boone T, Delaney J, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol. 2000;1(3):252-6.

For Research Use Only