Datasheet

ApoA5 Antibody
CATALOG NUMBER: 6271

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Chicken, Human
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:ApoA5 antibody can be used for detection of ApoA5 by Western blot at 1 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1304 - Human Liver Tissue Lysate
IMMUNOGEN:ApoA5 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of chicken ApoA5.

The immunogen is located within the last 50 amino acids of ApoA5.
HOST SPECIES:Rabbit

Properties

PURIFICATION:ApoA5 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:ApoA5 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:ApoA5 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:ApoA5 Antibody:
ACCESSION NO.:XP_417939
PROTEIN GI NO.:118101989
OFFICIAL SYMBOL:APOA5
GENE ID:419802

Background

BACKGROUND:ApoA5 Antibody: Apolipoprotein A4 (also known as ApoA-IV) is a plasma protein that is O-linked glycoprotein after proteolytic processing. ApoA4 is a major constituent of HDL and it also can be found on the surface of newly synthesized chylomicrons. The physiological function of ApoA4 is not completely identified so far, but several evidences from vitro studies indicate that this apolipoprotein involves in several steps of the reverse cholesterol transport pathway, which transports cholesterol from peripheral cells back to the liver.
REFERENCES: 1) Van der Vliet HN, Sammels MG, Leegwater AC, et al. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J. Biol. Chem. 2001; 276: 44512-20
2) Vu-Dac N, Gervois P, Jakel H, Nowak M, et al. Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators. J. Biol.Chem. 2003; 278:17982-5
3) Nilsson SK, Christensen S, Raarup MK, et al. Endocytosis of apolipoprotein AV by members of the low density lipoprotein receptor and the Vps10p domain receptor families" J. Biol. Chem. 2008; 283: 25920-7.

For Research Use Only