Datasheet

ALSFTD Antibody
CATALOG NUMBER: 8469

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, ICC, WB
APPLICATIONS:ALSFTD antibody can be used for the detection of ALSFTD by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry at 10 μg/ml.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1288 - A20 Cell Lysate
 2) Cat. No. 17-208 - A-20 Cell Slide
PREDICTED MOLECULAR WEIGHT:Predicted: 53 kDa

Observed: 52 kDa
SPECIFICITY:ALSFTD antibody is human, mouse and rat reactive. At least two isoforms are known to exist.
IMMUNOGEN:ALSFTD antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human ALSFTD.

The immunogen is located within amino acids 400 - 450 of ALSFTD.
HOST SPECIES:Rabbit

Properties

PURIFICATION:ALSFTD Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:ALSFTD Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:ALSFTD antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Amyotrophic lateral sclerosis with frontotemporal dementia, chromosome 9 open reading frame 72, C9orf72
ACCESSION NO.:NP_060795
PROTEIN GI NO.:37039612
OFFICIAL SYMBOL:ALSFTD
GENE ID:203228

Background

BACKGROUND:ALSFTD (C9orf72) is considered to play a role in gender determination (1). Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG (2). Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster (3,4).
REFERENCES: 1) Takada LT and Sha SJ. Neuropsychiatric features of C9orf72-associated behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease. Alzheimers Res. Ther. 2012; 4:38.
2) Coon EA, Whitwell JL, Parisi JE, et al. Right temporal variant frontotemporal dementia with motor neuron disease. J. Clin. Neurosci. 2012; 19:85-91.
3) Snowden JS, Rollinson S, Thompson JC, et al. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain 2012; 135:693-708.
4) Wen X, Tan W, Westergard T, et al. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron 2014; 84:1213-25.

For Research Use Only