Datasheet

Akirin1 Antibody
CATALOG NUMBER: 4801

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:H, M, R
TESTED APPLICATIONS:E, WB
APPLICATIONS:Akirin1 antibody can be used for detection of Akirin1 by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1464 - Rat Liver Tissue Lysate
IMMUNOGEN:Akirin1 antibody was raised against a 14 amino acid synthetic peptide near the center of the human Akirin1.
HOST SPECIES:Rabbit

Properties

PURIFICATION:Akirin1 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:Akirin1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Akirin1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:None

Additional Info

ALTERNATE NAMES:Akirin1 Antibody: STRF2, C1orf108, Akirin-1
ACCESSION NO.:CAI16710
PROTEIN GI NO.:55962136

Background

BACKGROUND
Akirin1 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
REFERENCES
1) Goto A, Matsushita K, Gesellchen V, et al. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat. Immunol.2008; 9:97-104.
2) Beutler B and Moresco EM. Akirins versus infection. Nat. Immunol.2008; 9:7-9.
3) Sutterwala FS and Flavell RA. Immunology: cascade into clarity. Nature2008; 451:254-5.
4) Tanji T and Ip YT. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol.2005; 26:193-8.

For Research Use Only