Datasheet

AGTR2 Antibody
CATALOG NUMBER: 5393

Availability: In stock

$0.00
Product Price Options

* Required Fields

$0.00
Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Sheep: (100%)
TESTED APPLICATIONS:ELISA, IHC-P, WB
APPLICATIONS:AGTR2 antibody can be used for detection of AGTR2 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1404 - Mouse Liver Tissue Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 40 kDa

Observed: 36 kDa
IMMUNOGEN:AGTR2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human AGTR2.

The immunogen is located within amino acids 220 - 270 of AGTR2.
HOST SPECIES:Rabbit

Properties

PURIFICATION:AGTR2 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:AGTR2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:AGTR2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:AGTR2 Antibody: AT2, ATGR2, MRX88, Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2
ACCESSION NO.:AAS45437
PROTEIN GI NO.:42766665
OFFICIAL SYMBOL:AGTR2
GENE ID:186

Background

BACKGROUND:AGTR2 Antibody: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.
REFERENCES: 1) Mottl AK, Shoham DA, and North KE. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review. Gen. in Med. 2008; 10:560-574.
2) Miyazaki Y and Ichikawa I. Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2001; 128:89-97.
3) Laflamme L, Gasparo M, Gallo JM, et al. Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors. J. Biol. Chem.1996; 271:22729-35.
4) Stoll M, Steckelings UM, Paul M, et al. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J. Clin. Invest. 1995; 95:651-7.

For Research Use Only