Datasheet

ADAMTSL5 Antibody
CATALOG NUMBER: 5687

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:ADAMTSL5 antibody can be used for detection of ADAMTSL5 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate
IMMUNOGEN:ADAMTSL5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ADAMTSL5.

The immunogen is located within the last 50 amino acids of ADAMTSL5.
HOST SPECIES:Chicken

Properties

PURIFICATION:ADAMTSL5 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:ADAMTSL5 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:ADAMTSL5 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgY
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:ADAMTSL5 Antibody: THSD6, THSD6, ADAMTS-like protein 5, Thrombospondin type-1 domain-containing protein 6, ADAMTSL-5
ACCESSION NO.:NP_998769
PROTEIN GI NO.:226442878
OFFICIAL SYMBOL:ADAMTSL5
GENE ID:339366

Background

BACKGROUND:ADAMTSL5 Antibody: ADAMTSL5 belongs to a large superfamily containing 20 ADAMTS proteases and at least eight ADAMTS-like proteins. ADAMTS proteases are secreted enzymes with a conserved organization that includes a metalloprotease domain and an ancillary domain containing one or more thrombospondin type 1 repeats (TSR). The ADAMTS-like subfamily comprises proteins homologous to the ADAMTS ancillary domains but lacking the protease domain and hence lacking catalytic activity. The exact role of ADAMTSL5 is currently unknown, but other ADAMTS-like proteins appear to have regulatory roles in the extracellular matrix.
REFERENCES: 1) Jones GC and Riley GP. ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arth. Res. and Ther.2005; 7:160-9.
2) Apte SS. A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J. Biol. Chem.2009; 284:31493-7.

For Research Use Only