Thymopoietin Antibody

Thymopoietin Antibody | catalog# 6605

Background

Thymopoietin (TMPO), also known as LAP2, is a widely expressed lem-domain-containing nuclear protein that is thought to play an important role in the regulation of nuclear architecture by binding lamin B1 and chromosomes in a manner regulated by phosphorylation during mitosis. Thymopoietin associates with nucleoplasmic lamins A/C, which are encoded by the dilated cardiomyopathy (DCM) gene LMNA; mutations in Thymopoietin disrupt this binding, suggesting that Thymopoietin may be a candidate disease gene for DCM.

Description

Western blot analysis of Thymopoietin in HeLa cell lysate with Thymopoietin antibody at 0.25 μg/mLl in (A) the absence and (B) the presence of blocking peptide.

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Specifications

Protein Accession Number

NP_003267

Purification

Affinity chromatography purified via peptide column

Clonality/Clone

This is a polyclonal antibody.

Host

Thymopoietin antibody was raised in rabbit.

Please use anti-rabbit secondary antibodies.

Specificity

At least three isoforms of Thymopoietin are known to exist; this antibody will detect all isoforms. Thymopoietin antibody is predicted to not cross-react with other LEM domain-containing proteins.

Immunogen

Thymopoietin antibody was raised against a 19 amino acid peptide near the amino terminus of human Thymopoietin.

Application

Thymopoietin antibody can be used for detection of Thymopoietin by Western blot at 0.25 – 0.5 μg/mL.

Tested Application

E, WB

Buffer

Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide

Cat. No. - 6605P - Thymopoietin Peptide

Storage

Thymopoietin antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Reference

Harris CA, Andryuk PJ, Cline SW, et al. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. Genomics 1995; 28:198-205.]