In eukaryotic cells, one of the most important and well studied regulatory events is protein phosphorylation. Protein phosphorylation is the addition of a phosphate group (PO4) to a protein substrate by a protein kinase. The removal of this phosphate group is dephosphorylation, and is carried out by protein phosphatases. The addition and removal of a phosphate group is a way of activating and inactivating many proteins within the cell. Proteins can have more than one phosphorylation site and saturation of all the phosphorylation sites on a protein can result in hyperphosphorylation. Phospho-specific antibodies can recognize the presence or absence of a phosphate group on a specific protein which can be extremely useful for understanding this regulation of protein activity.
ProSci has a wide variety of phospho-specific antibodies. These include antibodies against focal adhesion kinase (FAK), protein kinase C (PKC), microtubule associated protein kinase kinase (MEK), microtubule associated tau protein (Tau) and many other phospho-specific proteins. ProSci antibodies are appropriate for ELISA, western blot, and immunohistochemistry (IHC) applications as noted for each phospho-specific antibody.
|Product Name||Catalog #||App.||Reactivity||Description|
|14-3-3 Antibody||50-231||WB||H, M, R, D, ZF, S, B, C, X||14-3-3 (Ser58) Phospho-Specific|
|14-3-3 zeta Antibody||79-188||WB, IHC, IF||H, M, R||14-3-3 zeta (Phospho-Ser58)|
|14-3-3 zeta Antibody||79-354||WB, IHC||H, M, R||14-3-3 zeta (Ab-58)|
|4E-BP1 [pT46] Antibody||XBP-4031||WB||H, M||4E-BP1 [pT46]|
|4E-BP1 Antibody||79-205||WB, IHC||H||4E-BP1 (Phospho-Thr45)|
|4E-BP1 Antibody||79-367||WB, IHC||H, M, R||4E-BP1 (Ab-36)|
|4E-BP1 Antibody||79-368||WB, IHC, IF||H, M, R||4E-BP1 (Ab-45)|
|5 Lipoxygenase Antibody||50-244||WB||R, H||5-Lipoxygenase (Ser523) Phospho-Specific|
|a-catenin Antibody||79-503||WB||H, M||a-catenin (Phospho-Ser641)|
|a-catenin Antibody||79-620||WB||H, M||a-catenin (Ab-641)|