In eukaryotic cells, one of the most important and well studied regulatory events is protein phosphorylation. Protein phosphorylation is the addition of a phosphate group (PO4) to a protein substrate by a protein kinase. The removal of this phosphate group is dephosphorylation, and is carried out by protein phosphatases. The addition and removal of a phosphate group is a way of activating and inactivating many proteins within the cell. Proteins can have more than one phosphorylation site and saturation of all the phosphorylation sites on a protein can result in hyperphosphorylation. Phospho-specific antibodies can recognize the presence or absence of a phosphate group on a specific protein which can be extremely useful for understanding this regulation of protein activity.
ProSci has a wide variety of phospho-specific antibodies. These include antibodies against focal adhesion kinase (FAK), protein kinase C (PKC), microtubule associated protein kinase kinase (MEK), microtubule associated tau protein (Tau) and many other phospho-specific proteins. ProSci antibodies are appropriate for ELISA, western blot, and immunohistochemistry (IHC) applications as noted for each phospho-specific antibody.
|Product Name||Catalog #||App.||Reactivity||Description|
|MAP2 Antibody||79-737||WB||H, M, R||MAP2|
|MAP2K2 Antibody||48-876||WB, IHC||M, R||Mitogen-Activated Protein Kinase Kinase 2|
|MAP2K4 Antibody||48-877||WB, IHC||M, R||Mitogen-Activated Protein Kinase Kinase 4|
|MAP2K4 Antibody||48-878||WB, IHC||M, R||Mitogen-Activated Protein Kinase Kinase 4|
|MAP2K4 Antibody||79-657||WB||H, M, R||MAP2K4|
|MAP4 Antibody||48-784||WB, IHC||H||Microtubule-associated Protein 4|
|MAPKAPK-2 [pT334] glyc Antibody||XBP-4162||WB||H, M, Rb, HM||MAPKAPK-2 [pT334] glyc|
|MARCKS (Phospho-Phospho-Ser152/156) Antibody||XPS-1015||WB||H, M, R, X||MARCKS (Ser152,156) Phospho-Specific|
|MARCKS Antibody||79-599||WB||H, M, R||MARCKS (Ab-162)|
|MARCKS Antibody||48-705||WB, IHC||M, R||Myristoylated Alanine-rich C-kinase Substrate|