In eukaryotic cells, one of the most important and well studied regulatory events is protein phosphorylation. Protein phosphorylation is the addition of a phosphate group (PO4) to a protein substrate by a protein kinase. The removal of this phosphate group is dephosphorylation, and is carried out by protein phosphatases. The addition and removal of a phosphate group is a way of activating and inactivating many proteins within the cell. Proteins can have more than one phosphorylation site and saturation of all the phosphorylation sites on a protein can result in hyperphosphorylation. Phospho-specific antibodies can recognize the presence or absence of a phosphate group on a specific protein which can be extremely useful for understanding this regulation of protein activity.
ProSci has a wide variety of phospho-specific antibodies. These include antibodies against focal adhesion kinase (FAK), protein kinase C (PKC), microtubule associated protein kinase kinase (MEK), microtubule associated tau protein (Tau) and many other phospho-specific proteins. ProSci antibodies are appropriate for ELISA, western blot, and immunohistochemistry (IHC) applications as noted for each phospho-specific antibody.
|Product Name||Catalog #||App.||Reactivity||Description|
|F box and leucine-rich-repeat gene 4 Antibody||79-639||WB||Fruit fly||F box and leucine-rich-repeat gene 4|
|FABP4 Antibody||79-707||WB||H, M, R||FABP4|
|FAK [pS722] Antibody||XBP-4107||WB||H, M, R, C, X||FAK [pS722]|
|FAK [pS732] Antibody||XBP-4108||WB||M, R, H, C, X||FAK [pS732]|
|FAK [pS910] Antibody||XBP-4110||WB||H, M, R, C, X||FAK [pS910]|
|FAK [pY397] Antibody||XBP-4111||WB||H, M, X, Ds||FAK [pY397]|
|FAK [pY407] Antibody||XBP-4113||WB||H, M, R, C, X||FAK [pY407]|
|FAK [pY576] Antibody||XBP-4114||WB||H, M, R, C, X||FAK [pY576]|
|FAK [pY577] Antibody||XBP-4115||WB||H, M, R, C, X||FAK [pY577]|
|FAK [pY861] Antibody||XBP-4116||WB||H, M, C, R, X||FAK [pY861]|