NCR1 Monoclonal Antibody | catalog# 49-356
Recognises the human natural cytotoxicity receptor CD335, also known as NKp46. NKp46 is expressed on circulating NK cells and is reported to be a novel NK-specific cell surface molecule that is involved in human NK cell activation. Natural killer (NK) cells contribute to the innate immune response by directly lysing a variety of tumour cells and cells that are infected by viruses. Natural cytotoxicity receptors (NCR) are a family of Ig-like activation receptors that are reported to play an important role in tumour cell recognition. Three NCR have been reported to-date, which include NKp46, NKp30 and NKp44. The ligands for these NCR have not been identified. NKp46/CD335 is expressed on activated and resting NK cells but not on T or B cells and belongs to a family of receptors termed natural cytotoxicity receptors (NCR). Their engagement induces a strong activation of NK-mediated cytolysis and direct correlation exists between the surface density of NCR and the ability of NK cells to kill various target cells.