NCR1 Monoclonal Antibody | catalog# 49-356

Background

Recognises the human natural cytotoxicity receptor CD335, also known as NKp46. NKp46 is expressed on circulating NK cells and is reported to be a novel NK-specific cell surface molecule that is involved in human NK cell activation. Natural killer (NK) cells contribute to the innate immune response by directly lysing a variety of tumour cells and cells that are infected by viruses. Natural cytotoxicity receptors (NCR) are a family of Ig-like activation receptors that are reported to play an important role in tumour cell recognition. Three NCR have been reported to-date, which include NKp46, NKp30 and NKp44. The ligands for these NCR have not been identified. NKp46/CD335 is expressed on activated and resting NK cells but not on T or B cells and belongs to a family of receptors termed natural cytotoxicity receptors (NCR). Their engagement induces a strong activation of NK-mediated cytolysis and direct correlation exists between the surface density of NCR and the ability of NK cells to kill various target cells.

Description

Immunohistochemistry staining of NCR1 in lymph node tissue using NCR1 monoclonal Antibody.