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JMJD2C Antibody | catalog# 25-106

Background

JMJD2C is a member of the Jumonji domain 2 (JMJD2) family. It contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.

Description
JMJD2C Antibody
Western blot analysis of JMJD2C in HepG2 cell lysate using JMJD2C antibody at 1 μg/ml (6-18% gel).
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Specifications

Additional Names
JMJD2C, FLJ25949, GASC1, JHDM3C, KDM4C, KIAA0780, bA146B14.1
Positive Control
  • Cat. No. 1211 - HepG2 Cell Lysate]
Disclaimer
This product is for research use only.
Clonality/Clone
This is a polyclonal antibody.
Purification
Antibody is purified by peptide affinity chromatography method.
Host
JMJD2C antibody was raised in rabbit.

Please use anti-rabbit secondary antibodies.
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human JMJD2C.
Application
JMJD2C antibody can be used for detection of JMJD2C by ELISA at 1:62500. JMJD2C antibody can be used for detection of JMJD2C by western blot at 1 μg/ml, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Tested Application
E, WB
Buffer
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μl of distilled water. Final antibody concentration is 1 mg/ml.
Storage
For short periods of storage (days) store at 4˚C. For longer periods of storage, store JMJD2C antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Species Reactivity
H, M
Protein Accession Number
NP_055876
Molecular Weight
120 kDa
Reference
  1. Katoh, Y. (2007) Int. J. Mol. Med. 20 (2), 269-273.]