Immunology Antibodies
Immunology is a tremendously broad research area which focuses on the immune system. Much of the research is centered on the control of the major lymphocytes. B lymphocytes, killer T cells, and helper T cells are the main groups of immune cells. T cells are involved in cell mediated immune response. Helper T cells recognize antigens bound to Class I major histocompatibility complex (Class I MHC) and killer T cells recognize antigens bound to Class II major histocompatibility complex (Class II MHC). B lymphocytes present antigens on unique major histocompatibility complex (MHC) molecules. When this complex on the B lymphocyte is recognized by a matching T cell, the T cell releases cytokines which activate the B lymphocyte and cause it to produce millions of antibodies.
Activation induced cytidine deaminase (AID), interleukin-23 (IL-23), a homolog to toll-like receptor 4 called RP105, interleukin-27 (IL-27), and T cell immunoglobulin and mucin domain containing protein 1 and 4 (TIM1 and TIM4) are all proteins which have strong implications in recent immunology research. Activation induced cytidine deaminase (AID) is necessary for somatic hypermutation and class switch recombination in B lymphocytes. Interleukin-23 (IL-23) has many functions associated with immunology, including enhancement of memory T cell proliferation, enhancement of activated T cell release of IFN-gamma, IL-12, and TNF-α, as well as activating macrophages to produce TNF-α and nitric oxide. Interleukin-27 (IL-27) has a wider influence in immunology by playing a roll in limiting the duration and intensity of responses of the adaptive immune system. T cell immunoglobulin and mucin domain containing protein 1 (TIM1) is genetically linked to asthma, and it is a receptor for hepatitis A virus, and the ligand of TIM1 is T cell immunoglobulin and mucin domain containing protein 4 (TIM4).
ProSci has many immunology antibodies, including antibodies to the proteins mentioned here. ProSci's Immunology antibodies include antibodies against a homolog to toll-like receptor 4 called RP105, activation induced cytidine deaminase (AID), interleukin 23 (IL-23), T cell immunoglobulin and mucin domain containing protein 1 and 4 (TIM1 and TIM4) and interleukin 27 (IL-27). ProSci antibodies are appropriate for ELISA, western blot, and immunohistochemistry (IHC) applications as noted for each immunology antibody.
| Product Name | Catalog # | App. | Reactivity | Description |
|---|---|---|---|---|
| OAS1 Antibody | 27-235 | E, WB | H | OAS1 (2',5'-oligoadenylate synthetase 1, 40/46kDa) |
| OAS1 Antibody | XW-7420 | WB | H | Oligoadenylate synthetase 1 isoform E16 |
| OASL Antibody | 25-618 | E, WB | H | OASL (2'-5'-oligoadenylate synthetase-like) |
| OMI Antibody | 3319 | E, WB, IHC, IF | H | (CT) IAP inhibitor |
| OPRK1 Antibody | 27-232 | E, WB | H | OPRK1 (opioid receptor, kappa 1) |
| OPTN Antibody | 49-349 | WB, IHC | M, R, P | Optineurin |
| ORAI Detection Set | PSI-1819 | WB | see datasheet | ORAI1, ORAI2, ORAI3, STIM1, STIM2 |
| ORAI-1 Antibody | 39-871 | E, WB, IHC | H, M | (CT) ORAI-1 |
| ORAI1 Antibody | 4041 | E, WB, IHC, IF | H, M | (NT) a T cell calcium channel |
| ORAI1 Antibody | 4281 | E, WB, IHC | H, M | (CT) a T cell calcium channel |
| ORAI1 Antibody | 46-765 | E, WB | H | ORAI1 / CRACM1 |
| ORAI1 Monoclonal Antibody | PM-5205 | E, WB, IHC, IF | H, M, R | a T cell calcium channel |
| ORAI1 Monoclonal Antibody | PM-5207 | E, WB, IHC, IF | H, M, R | a T cell calcium channel |
| ORAI2 Antibody | 4111 | E, WB, ICC, IF | H, M | (CT) a T cell calcium channel |
| ORAI3 Antibody | 4117 | E, WB, ICC | H, M, R | (NT) a T cell calcium channel |
| ORAI3 Antibody | 4215 | E, WB, ICC, IF | H, M | (CT) a T cell calcium channel |
| ORAI3 Monoclonal Antibody | PM-4911 | E, WB, IHC, IF | H, R | Transmembrane protein 142C |
| ORAI3 Monoclonal Antibody | PM-4913 | E, WB | H, R | Transmembrane protein 142C |
| ORM1 Antibody | XW-7661 | E, WB | H | a-1-acid glycoprotein 1, AGP 1, Orosomucoid-1, OMD |
| ORM1 Antibody | 49-461 | E, WB, IHC, IF, IP | H | (CT) Alpha-1-acid Glycoprotein 2 |
| OVA Monoclonal Antibody | 32-200 | E, WB | n/a | |
| OXSM Antibody | 26-119 | E, WB | H, M, R | OXSM (3-oxoacyl-ACP synthase, mitochondrial) |

