Immunology is a tremendously broad research area which focuses on the immune system. Much of the research is centered on the control of the major lymphocytes. B lymphocytes, killer T cells, and helper T cells are the main groups of immune cells. T cells are involved in cell mediated immune response. Helper T cells recognize antigens bound to Class I major histocompatibility complex (Class I MHC) and killer T cells recognize antigens bound to Class II major histocompatibility complex (Class II MHC). B lymphocytes present antigens on unique major histocompatibility complex (MHC) molecules. When this complex on the B lymphocyte is recognized by a matching T cell, the T cell releases cytokines which activate the B lymphocyte and cause it to produce millions of antibodies.
Activation induced cytidine deaminase (AID), interleukin-23 (IL-23), a homolog to toll-like receptor 4 called RP105, interleukin-27 (IL-27), and T cell immunoglobulin and mucin domain containing protein 1 and 4 (TIM1 and TIM4) are all proteins which have strong implications in recent immunology research. Activation induced cytidine deaminase (AID) is necessary for somatic hypermutation and class switch recombination in B lymphocytes. Interleukin-23 (IL-23) has many functions associated with immunology, including enhancement of memory T cell proliferation, enhancement of activated T cell release of IFN-gamma, IL-12, and TNF-α, as well as activating macrophages to produce TNF-α and nitric oxide. Interleukin-27 (IL-27) has a wider influence in immunology by playing a roll in limiting the duration and intensity of responses of the adaptive immune system. T cell immunoglobulin and mucin domain containing protein 1 (TIM1) is genetically linked to asthma, and it is a receptor for hepatitis A virus, and the ligand of TIM1 is T cell immunoglobulin and mucin domain containing protein 4 (TIM4).
ProSci has many immunology antibodies, including antibodies to the proteins mentioned here. ProSci's Immunology antibodies include antibodies against a homolog to toll-like receptor 4 called RP105, activation induced cytidine deaminase (AID), interleukin 23 (IL-23), T cell immunoglobulin and mucin domain containing protein 1 and 4 (TIM1 and TIM4) and interleukin 27 (IL-27). ProSci antibodies are appropriate for ELISA, western blot, and immunohistochemistry (IHC) applications as noted for each immunology antibody.
|Product Name||Catalog #||App.||Reactivity||Description|
|DCLRE1C Antibody||XW-7140||WB||H||DNA cross-link repair 1C; artemis protein|
|DDAH1 Antibody||26-938||E, WB||H, M, R||DDAH1 (dimethylarginine dimethylaminohydrolase 1)|
|DDAH2 Antibody||27-196||E, WB||H, M, R||DDAH2 (dimethylarginine dimethylaminohydrolase 2)|
|DDX54 Antibody||28-505||E, WB||H, D||DDX54 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 54)|
|DEPDC7 Antibody||30-754||E, WB||H||DEPDC7 (DEP domain containing 7)|
|DFNA5 Antibody||30-158||E, WB, IHC||H||DFNA5 (deafness, autosomal dominant 5)|
|DGKE Antibody||26-054||E, WB||H||DGKE (diacylglycerol kinase, epsilon 64kDa)|
|DGKH Antibody||26-073||E, WB||H, M, R||DGKH (diacylglycerol kinase, eta)|
|DIRAS1 Antibody||26-699||E, WB||H, M, R||DIRAS1 (DIRAS family, GTP-binding RAS-like 1)|
|DKFZP564J0863 Antibody||26-190||E, WB||H, M, R||DKFZP564J0863 (hypothetical protein DKFZP564J0863)|
|DLG7 Antibody||26-109||E, WB||H, M||DLG7 (discs, large homolog 7)|
|DNTT Antibody||30-788||E, WB||H, M, R||DNTT (deoxynucleotidyltransferase, terminal)|
|DPP4 Antibody||XW-7151||ICC||H||Dipeptidylpeptidase IV (CD26)|
|DTNB Antibody||26-124||E, WB||H, M, R||DTNB (dystrobrevin, beta)|
|DUT Antibody||30-136||E, WB, IHC||H, M, R, D||DUT (dUTP pyrophosphatase)|
|DVL1 Antibody||27-500||E, WB||H||DVL1 (dishevelled, dsh homolog 1 (Drosophila))|
|DXYS155E Antibody||28-033||E, WB, IHC||H, D||DXYS155E (splicing factor, arginine/serine-rich 17|