Growth Factor Antibodies
Growth factors are a large family of proteins which are responsible for stimulating or inhibiting cellular proliferation and differentiation, angiogenesis, and neurotrophic effects. Growth factors typically bind to the extracellular domain of membrane growth factor receptors which activate the intracellular domain. This sets in motion a signaling cascade, eventually leading to a change in cellular proliferation and differentiation. Changes in these growth factor signaling pathways can lead to abnormal cellular growth.
Growth factors can cause an extremely wide array of changes upon binding to their receptors, and are implicated in many cellular processes. Growth factors such as platelet derived growth factor (PDF) and fibroblast growth factor (FGF) are involved in the cell cycle. Platelet derived growth factor (PDF) and fibroblast growth factor (FGF) are each required for progression through the G1 phase of the cell cycle.
ProSci has a wide array of growth factor antibodies, to many different groups of growth factors. These primary antibodies include antibodies against brain derived neurotrophic factor (BDNF), epidermal growth factor (EGF), fibroblast growth factor (FGF), bone morphogenic protein-2 (BMP-2) as well as many growth factor receptors.
ProSci antibodies are appropriate for ELISA, western blot, and immunohistochemistry (IHC) applications as noted for each growth factor antibody.